一、个人简介

   李红燕，药物化学专业博士研究生，2020年05月加入澳门永利yl6776，主要从事海洋生物资源化学与生物活性、功效因子稳态化及纳米递送等相关研究。主持省部级科研项目多项，在《Carbohydrate Polymers》、《International Journal of Biological Macromolecules》等国际学术期刊发表SCI论文40余篇，申请发明专利多件，担任《Carbohydrate Polymers》、《International Journal of Biological Macromolecules》、《Glycoconjugate Journal》等国际学术期刊审稿人。

二、研究方向

1. 海洋生物资源活性成分化学结构及功能评价

2. 海洋生物功效因子稳态化及纳米递送

三、教育及工作经历

2020.5-至今     澳门永利yl6776

2017.6-2020.4   中国海洋大学 食品科学与工程学院 博士后

2011.7-2017.5   河北大学 化学与材料科学学院

2006.9-2011.6   中国海洋大学 药物化学 博士

2004.7-2006.8   山东淄博新达制药有限公司 质量部工程师

2000.9-2004.6   湖北中医药大学 药学 学士

四、个人荣誉与获奖

1. 第八届全国大学生生命科学竞赛（创新组CULSC2023CXCY1846），国家三等奖，指导老师

2. 第八届全国大学生生命科学竞赛（创新组CULSC2023SD-2-078），山东省二等奖，指导老师

3. 2023年度大学生创新创业项目（S202310426309），省级立项，指导老师

4. 2022年度大学生创新创业项目，校级立项，指导老师

5. 2020年度山东省食品科学技术学会科学技术奖叁等奖，6/10

五、承担的主要科研项目

1. 国家自然科学基金项目，32072348，嗜盐菌代谢影响传统发酵虾酱特征风味形成的分子机制，参与

2. 澳门永利yl6776高层次人才启动经费，主持

3. 食品质量与安全北京实验室（FQS-202108），壳聚糖衍生物对扇贝中PSTs毒素的消减机制研究，主持

4. 青岛宝创生物科技有限公司，海洋真菌胞外多糖研发技术，主持

5. 中国博士后科学基金项目，2018M642706，海参皂苷靶向长效纳米脂质体的制备及抗乳腺癌活性研究，主持

6. 山东省博士后创新项目，肝靶向苦菜多糖的制备、结构及抗肝癌作用研究，主持

7. 河北省自然科学基金项目，B2015201069，板栗多糖资源开发的基础研究，主持

8. 河北省教育厅项目，QN2014131，以拓扑异构酶I为靶点的板栗多糖活性片段的筛选与结构表征，主持

9. 国家自然科学基金项目，41076086，礁膜抗凝血活性鼠李聚糖硫酸酯的可控降解与构效关系研究，参与

六、教学情况

1. 主讲本科生课程《海洋资源学》、《海洋药物》

2. 主讲研究生课程《海洋资源的开发与利用》、《海洋生物资源化学》、《生物活性物质波谱解析》

七、论文与专利

       1. Che Hongxia, Wang Xiyu, He Shusen, Dong Xiufang, Lv Liangtao, Xie Wancui*, Li Hongyan*. Orally administered selenium-containing α-D-1,6-glucan and α-D-1,6-glucan relief early cognitive deficit in APP/PS1 mice. International Journal of Biological Macromolecules, 2024, 257, 128539.

        2. Li Hongyan*, Cui Huanhuan, Cong Peixu, Xu Jie, Xie Wancui, Wang Yuming, Xue Changhu. Echinoside A from Pearsonothuria graeffei exert the cytotoxicity to MDA-MB-231 cells via mitochondrial and modulation of PI3K/Akt/mTOR pathway. Journal of Ocean University of China, 2023, 22, 205-212.

        3. Li Hongyan*, Wang Yifan, Chen Yan, Wang Shuxin Zhao Yifan, Sun Jinyuan*. Arabinogalactan from Ixeris chinensis (Thunb.) Nakai as a stabilizer to decorate SeNPs and enhance their anti-hepatocellular carcinoma activity via the mitochondrial pathway. Journal of Carbohydrate Chemistry, 2022, 41, 329-345.

        4. Li Hongyan*, Cao Wanxiu, Xie Jingwen, Hongxia Che, Dong Xiufang, Song Lin, Xie Wancui*. The α-D-1,6-glucan from Castanea mollissima Blume alleviates dextran sulfate sodium-induced colitis in vivo. Carbohydrate Polymers, 2022, 289, 119410.

        5. Li Hongyan*, Che Hongxia, Xie Jingwen, Dong Xiufang, Song Lin, Xie Wancui, Sun Jinyuan*. Supplementary selenium in the form of selenylation α-D-1,6-glucan ameliorates dextran sulfate sodium induced colitis in vivo. International Journal of Biological Macromolecules, 2022, 195, 67-74.

        6. Li Hongyan, Xie Wancui, Sun Haihong, Cao Kewei, Yang, Xihong*, Effect of structural characterization of the fungal polysaccharides on their immunomodulatory activity. International Journal of Biological Macromolecules, 2020, 164: 3603-3610.

        7. Li Hongyan*; Xie Wancui; Qiao Xing; Cui Huanhuan; Yang Xihong; Xue Changhu, Structural characterization of arabinogalactan extracted from Ixeris chinensis (Thunb.) Nakai and its immunomodulatory effect on RAW264.7 macrophages. International Journal of Biological Macromolecules, 2020, 143: 977-983.

        8. Li Hongyan*, Liu Dandan, Li Shenghui, Xue Changhu*, Synthesis and cytotoxicity of selenium nanoparticles stabilized by α-D-glucan from Castanea mollissima Blume. International Journal of Biological Macromolecules, 2019, 129, 818-826.

        9. Cui Huanhuan, Li Hongyan*, Wang Yingxing, Li Shenghui, Xue Changhu*, Structural characterization and biological activity of galactoglucan from Castanea mollissima Blume. Journal of Carbohydrate Chemistry, 2019, 38, 398-411.

        10. Li Hongyan*, Cao Kewei, Cong Peixu, Liu Yanjun, Cui Huanhuan, Xue Changhu*, Structure characterization and antitumor activity of the extracellular polysaccharide from the marine fungus Hansfordia sinuosae. Carbohydrate Polymers, 2018, 190, 87-94.

        11. Li Hongyan, Wang Yingxing, Wang Chao, Zhang Shaohan, Li Shenghui*, Zhou Guoqiang, Wang Shuxiang, Zhang Jinchao*, Extraction, selenylation modification and antitumor activity of the glucan from Castanea mollissima Blume. Glycoconjugate Journal, 2017, 34, 207-217.

        12. Li Hongyan*, Yu He, Zhu Huajie*. Structure studies of the extracellular polysaccharide from Trichoderma sp. KK19L1 and its antitumor effect via cell cycle arrest and apoptosis, Applied Biochemistry and Biotechnology, 2017, 182:128-141.

        13. Li Hongyan*, Liu Xin, Xu Yan, Wang Xiaoke, Zhu Huajie*, Structure and antitumor activity of the extracellular polysaccharides from Aspergillus aculeatus via apoptosis and cell cycle arrest. Glycoconjugate Journal, 2016, 33, 975-984.

        14. Li Hongyan*, Gao Tong, Wang Jingchen, Tian Shasha, Yuan Xin，Zhu Huajie*, Structure identification and antitumor activity of the extracellular polysaccharide from Aspergillus terreus. Process Biochemistry, 2016, 51, 1714-1720.

        15. Li Hongyan, Mao Wenjun*, Hou Yujiao, Gao Yan, Qi Xiaohui, Zhao Chunqi, Chen Yin, Chen Yanli, Li Na, Wang Chunyan, Preparation, structure and anticoagulant activity of a low molecular weight fraction produced by mild acid hydrolysis of the sulfated rhamnan from Monostroma latissimum. Bioresource Technology, 2012, 114, 414-418.

        16. Li Hongyan, Mao Wenjun*, Chen Yin, Ren Sumei, Qi Xiaohui, Chen Yanli, Zhao Chunqi, Li Na, Wang Chunyan, Lin Cong, Yan Mengxia, Shan Jimiao, Sequence analysis of the sulfated rhamno-oligosaccharides derived from a sulfated rhamnan. Carbohydrate Polymers, 2012, 90:1299-1304.

        17. Li Hongyan, Mao Wenjun*, Zhang Xiuli, Qi Xiaohui, Chen Yin, Chen Yanli, Xu Jian, Zhao Chunqi, Hou Yujiao, Yang Yupin, Li Na, Wang Chunyan, Structural characterization of an anticoagulant -active sulfated polysaccharide isolated from green alga Monostroma latissimum. Carbohydrate Polymers, 2011, 85, 394-400.

        18. Mao Wenjun*, Li Hongyan, Li Yi, Zhang Huijuan, Qi Xiaohui, Sun Haihong, Chen Yin, Guo Shoudong, Chemical characteristic and anticoagulant activity of the sulfated polysaccharide isolated from Monostroma latissimum (Chlorophyta), International Journal of Biological Macromolecules, 2009, 44:70-74.

专利：

1. 李红燕，解万翠，杨锡洪，车红霞，董秀芳，宋琳。一种丹皮线性α-D-1,4-葡聚糖及其制备方法和应用。2022.6.7 ZL202110883581.8

2. 李红燕，解万翠，杨锡洪，车红霞，董秀芳，宋琳。一种包载海参皂苷的自组装纳米体系及其制备方法和应用。2022.6.3 ZL202011622525.0

3. 李红燕，解万翠，杨锡洪，宋琳，车红霞，董秀芳。一种天麻大分子线性直链葡聚糖及其制备方法和应用。2022.5.31 ZL202011469544.4

4. 李红燕，王应杏，张金超，王书香，李胜辉，周国强，刘丹丹。板栗种仁α-1,6-葡聚糖及其制备方法以及在抗肿瘤药物中的应用，2017.8.25，中国，ZL201510333089.8

5. 薛长湖，李红燕，崔欢欢，柯枭，徐杰，王玉明，李兆杰。一种可供注射给药的海参皂苷纳米脂质体，其制备方法及在抗肿瘤药物中的应用，2021.7.23，中国，ZL201910203903.2

6. 李红燕，解万翠，杨锡洪，董秀芳，宋琳，车红霞。一种可供注射的海参皂苷介孔二氧化硅纳米复合物及其制备方法和应用。202011625912.X

7. 李红燕，解万翠，杨锡洪，董秀芳，车红霞，宋琳。一种虾青素-壳聚糖自组装纳米复合物及其制备方法和应用。202110955254.9。

8. 李红燕，解万翠，杨锡洪，车红霞，董秀芳，宋琳。一种透明质酸-虾青素纳米复合物及其制备方法与应用。202111562607.5。

9. 李红燕，解万翠，杨锡洪，董秀芳，车红霞，宋琳。A hyaluronic acid-astaxanthin self-assembled nano system and the preparation method and its application. Patent number: 2021106295. 国际专利

10. 李红燕，解万翠，杨锡洪，车红霞，董秀芳，宋琳。Extraction and preparation of the acidic polysaccharide extracted from Kaempfeia galangal L and its application in antibacterial preservation. Patent number: 2021106002. 国际专利